Discriminating between negative cooperativity and ligand binding to independent sites using pre-equilibrium properties of binding curves

• Federico Sevlever,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Software, Writing – original draft, Writing – review & editing

  Affiliations Department of Physiology, Molecular and Cellular Biology, University of Buenos Aires, Buenos Aires, Argentina, Institute of Physiology, Molecular Biology and Neurosciences, National Research Council (CONICET), Buenos Aires, Argentina

  http://orcid.org/0000-0001-6749-4162

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• Juan Pablo Di Bella,

  Roles Conceptualization, Investigation

  Affiliations Department of Physiology, Molecular and Cellular Biology, University of Buenos Aires, Buenos Aires, Argentina, Institute of Physiology, Molecular Biology and Neurosciences, National Research Council (CONICET), Buenos Aires, Argentina

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• Alejandra C. Ventura

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: alejvent@fbmc.fcen.uba.ar

  Affiliations Department of Physiology, Molecular and Cellular Biology, University of Buenos Aires, Buenos Aires, Argentina, Institute of Physiology, Molecular Biology and Neurosciences, National Research Council (CONICET), Buenos Aires, Argentina

  http://orcid.org/0000-0002-5275-3827

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