Perturbation biology links temporal protein changes to drug responses in a melanoma cell line

• Elin Nyman ,

  Contributed equally to this work with: Elin Nyman, Richard R. Stein

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: pertmel.a2058@gmail.com (EN); pertmel.a2058@gmail.com (RRS); pertmel.a2058@gmail.com (NPG); pertmel.a2058@gmail.com (CS)

  Affiliations Department of Cell Biology, Harvard Medical School, Boston, MA 02115, U.S.A., cBio Center, Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, U.S.A., Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, OR 97239, U.S.A., Department of Biomedical Engineering, Linköping University, Linköping 58185, Sweden

  http://orcid.org/0000-0002-4261-0291

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• Richard R. Stein ,

  Contributed equally to this work with: Elin Nyman, Richard R. Stein

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: pertmel.a2058@gmail.com (EN); pertmel.a2058@gmail.com (RRS); pertmel.a2058@gmail.com (NPG); pertmel.a2058@gmail.com (CS)

  Current address: Novartis Institutes for BioMedical Research, Basel 4056, Switzerland

  Affiliations cBio Center, Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, U.S.A., Harvard School of Public Health, Boston, MA 02115, U.S.A., Department of Systems Biology, Harvard Medical School, Boston, MA 02115, U.S.A., Broad Institute of MIT and Harvard, Cambridge, MA 02142, U.S.A.

  http://orcid.org/0000-0002-5110-6863

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• Xiaohong Jing,

  Roles Data curation, Investigation

  Affiliation Memorial Sloan Kettering Cancer Center, New York, NY 10065 U.S.A.

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• Weiqing Wang,

  Roles Data curation, Investigation

  Affiliation Memorial Sloan Kettering Cancer Center, New York, NY 10065 U.S.A.

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• Benjamin Marks,

  Roles Investigation

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, MA 02115, U.S.A.

  http://orcid.org/0000-0003-0462-4040

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• Ioannis K. Zervantonakis,

  Roles Resources

  Affiliation Department of Cell Biology, Harvard Medical School, Boston, MA 02115, U.S.A.

  http://orcid.org/0000-0003-2386-9553

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• Anil Korkut,

  Roles Conceptualization, Writing – original draft

  Affiliation University of Texas MD Anderson Cancer Center, Houston, TX 77030 U.S.A.

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• Nicholas P. Gauthier ,

  Roles Conceptualization, Data curation, Formal analysis, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: pertmel.a2058@gmail.com (EN); pertmel.a2058@gmail.com (RRS); pertmel.a2058@gmail.com (NPG); pertmel.a2058@gmail.com (CS)

  ¶‡Joint senior authors

  Affiliations Department of Cell Biology, Harvard Medical School, Boston, MA 02115, U.S.A., cBio Center, Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, U.S.A., Broad Institute of MIT and Harvard, Cambridge, MA 02142, U.S.A.

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• Chris Sander

  Roles Conceptualization, Funding acquisition, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: pertmel.a2058@gmail.com (EN); pertmel.a2058@gmail.com (RRS); pertmel.a2058@gmail.com (NPG); pertmel.a2058@gmail.com (CS)

  ¶‡Joint senior authors

  Affiliations Department of Cell Biology, Harvard Medical School, Boston, MA 02115, U.S.A., cBio Center, Department of Data Science, Dana-Farber Cancer Institute, Boston, MA 02215, U.S.A., Broad Institute of MIT and Harvard, Cambridge, MA 02142, U.S.A.

  http://orcid.org/0000-0001-6059-6270

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