Insights into adenosine A2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions

Agustín Bruzzese; James A. R. Dalton; Jesús Giraldo

doi:10.1371/journal.pcbi.1007818

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Peer-reviewed

Research Article

Insights into adenosine A_2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions

Agustín Bruzzese,

Roles Formal analysis, Investigation, Methodology, Writing – original draft

Affiliations Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain, Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain
⨯
James A. R. Dalton ,

Roles Conceptualization, Formal analysis, Investigation, Methodology, Supervision, Writing – original draft, Writing – review & editing

* E-mail: James.Dalton@uab.es (JARD); Jesus.Giraldo@uab.es (JG)

Affiliations Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain, Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain

http://orcid.org/0000-0002-5279-4581

⨯
Jesús Giraldo

Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – review & editing

* E-mail: James.Dalton@uab.es (JARD); Jesus.Giraldo@uab.es (JG)

Affiliations Laboratory of Molecular Neuropharmacology and Bioinformatics, Unitat de Bioestadística and Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain, Unitat de Neurociència Traslacional, Parc Taulí Hospital Universitari, Institut d’Investigació i Innovació Parc Taulí (I3PT), Institut de Neurociències, Universitat Autònoma de Barcelona, Bellaterra, Spain, Instituto de Salud Carlos III, Centro de Investigación Biomédica en Red de Salud Mental, CIBERSAM, Spain

http://orcid.org/0000-0001-7082-4695

⨯

Insights into adenosine A_2A receptor activation through cooperative modulation of agonist and allosteric lipid interactions

Agustín Bruzzese,
James A. R. Dalton,
Jesús Giraldo

Published: April 16, 2020
https://doi.org/10.1371/journal.pcbi.1007818

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Adenosine
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Crystal structure
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Biochemical simulations
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Intracellular receptors
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Lipids
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G protein coupled receptors
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Protein interactions
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Membrane receptor signaling
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