Mutation severity spectrum of rare alleles in the human genome is predictive of disease type

• Jimin Pei,

  Roles Formal analysis, Methodology, Software, Writing – original draft

  Affiliation Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Lisa N. Kinch,

  Roles Formal analysis, Writing – original draft

  Affiliation Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Zbyszek Otwinowski,

  Roles Conceptualization

  Affiliation Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

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• Nick V. Grishin

  Roles Conceptualization, Methodology, Writing – review & editing

  * E-mail: grishin@chop.swmed.edu

  Affiliations Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America, Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas, United States of America

  http://orcid.org/0000-0003-4108-1153

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