Dysregulated biodynamics in metabolic attractor systems precede the emergence of amyotrophic lateral sclerosis

• Paul Curtin ,

  Contributed equally to this work with: Paul Curtin, Christine Austin, Austen Curtin, Chris Gennings, Manish Arora

  Roles Conceptualization, Formal analysis, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: paul.curtin@mssm.edu(PC); manish.arora@mssm.edu(MA)

  Affiliation Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

  http://orcid.org/0000-0003-3749-3868

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• Christine Austin ,

  Contributed equally to this work with: Paul Curtin, Christine Austin, Austen Curtin, Chris Gennings, Manish Arora

  Roles Conceptualization, Data curation, Funding acquisition, Writing – original draft

  Affiliation Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

  http://orcid.org/0000-0002-9966-0492

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• Austen Curtin ,

  Contributed equally to this work with: Paul Curtin, Christine Austin, Austen Curtin, Chris Gennings, Manish Arora

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft

  Affiliation Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

  ⨯
• Chris Gennings ,

  Contributed equally to this work with: Paul Curtin, Christine Austin, Austen Curtin, Chris Gennings, Manish Arora

  Roles Conceptualization, Writing – original draft

  Affiliation Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

  http://orcid.org/0000-0002-6058-5907

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• Claudia Figueroa-Romero,

  Roles Data curation, Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America

  http://orcid.org/0000-0001-7546-4190

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• Kristen A. Mikhail,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America

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• Tatiana M. Botero,

  Roles Data curation, Investigation, Methodology

  Affiliation Department of Cariology, Restorative Sciences and Endodontics, School of Dentistry University of Michigan, Ann Arbor, MI, United States of America

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• Stephen A. Goutman,

  Roles Funding acquisition, Investigation, Writing – review & editing

  Affiliation Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America

  http://orcid.org/0000-0001-8780-6637

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• Eva L. Feldman,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliation Department of Neurology, University of Michigan, Ann Arbor, MI, United States of America

  http://orcid.org/0000-0002-9162-2694

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• Manish Arora

  Contributed equally to this work with: Paul Curtin, Christine Austin, Austen Curtin, Chris Gennings, Manish Arora

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: paul.curtin@mssm.edu(PC); manish.arora@mssm.edu(MA)

  Affiliation Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States of America

  http://orcid.org/0000-0002-3350-4657

  ⨯