Hydra: A mixture modeling framework for subtyping pediatric cancer cohorts using multimodal gene expression signatures

• Jacob Pfeil ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jpfeil@ucsc.edu

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0002-8773-8520

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• Lauren M. Sanders,

  Roles Conceptualization, Formal analysis, Investigation, Writing – review & editing

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America, Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America

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• Ioannis Anastopoulos,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Writing – review & editing

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0002-6279-0648

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• A. Geoffrey Lyle,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Writing – review & editing

  Affiliations Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America, Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0002-3435-526X

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• Alana S. Weinstein,

  Roles Conceptualization, Methodology, Writing – review & editing

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0002-1563-9072

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• Yuanqing Xue,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0003-1892-6787

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• Andrew Blair,

  Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – review & editing

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

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• Holly C. Beale,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Supervision, Writing – review & editing

  Affiliations Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America, Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0003-4091-538X

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• Alex Lee,

  Roles Conceptualization, Investigation, Methodology, Software, Validation, Writing – review & editing

  Affiliation Department of Pediatrics, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, United States of America

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• Stanley G. Leung,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Pediatrics, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, United States of America

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• Phuong T. Dinh,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Validation, Visualization, Writing – review & editing

  Affiliation Department of Pediatrics, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, United States of America

  http://orcid.org/0000-0002-0273-1603

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• Avanthi Tayi Shah,

  Roles Conceptualization, Data curation, Investigation, Validation, Writing – review & editing

  Affiliation Department of Pediatrics, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, United States of America

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• Marcus R. Breese,

  Roles Data curation, Formal analysis, Investigation, Validation, Writing – review & editing

  Affiliation Department of Pediatrics, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, United States of America

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• W. Patrick Devine,

  Roles Data curation, Formal analysis, Investigation, Supervision, Validation, Visualization, Writing – review & editing

  Affiliation Department of Anatomic Pathology, University of California, San Francisco, California, San Francisco, United States of America

  http://orcid.org/0000-0003-4634-8830

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• Isabel Bjork,

  Roles Funding acquisition, Project administration, Resources, Software, Supervision, Writing – review & editing

  Affiliation Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

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• Sofie R. Salama ,

  Roles Conceptualization, Funding acquisition, Methodology, Project administration, Resources, Supervision, Writing – review & editing

  ¶‡ Senior authorship.

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America, Howard Hughes Medical Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0001-6999-7193

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• E. Alejandro Sweet-Cordero ,

  Roles Conceptualization, Data curation, Investigation, Methodology, Resources, Supervision, Validation, Visualization, Writing – review & editing

  ¶‡ Senior authorship.

  Affiliation Department of Pediatrics, Division of Hematology and Oncology, University of California, San Francisco, San Francisco, California, United States of America

  http://orcid.org/0000-0002-9787-9351

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• David Haussler ,

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Writing – review & editing

  ¶‡ Senior authorship.

  Affiliations Department of Biomolecular Engineering, University of California, Santa Cruz, Santa Cruz, California, United States of America, Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America, Howard Hughes Medical Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America

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•  [ ... ],
• Olena Morozova Vaske

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – review & editing

  ¶‡ Senior authorship.

  Affiliations Genomics Institute, University of California, Santa Cruz, Santa Cruz, California, United States of America, Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, Santa Cruz, California, United States of America

  http://orcid.org/0000-0002-1677-417X

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