Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

• Jamie L. Nosbisch,

  Roles Data curation, Formal analysis, Investigation, Writing – original draft, Writing – review & editing

  Affiliation Biomathematics Graduate Program, North Carolina State University, Raleigh, North Carolina, United States of America

  http://orcid.org/0000-0001-9677-9765

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• Anisur Rahman,

  Roles Data curation, Formal analysis, Writing – review & editing

  Affiliation Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America

  http://orcid.org/0000-0002-5203-8188

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• Krithika Mohan,

  Roles Conceptualization, Writing – review & editing

  Affiliation Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America

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• Timothy C. Elston,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Department of Pharmacology, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

  http://orcid.org/0000-0002-4601-2117

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• James E. Bear,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Department of Cell Biology and Physiology, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, North Carolina, United States of America

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• Jason M. Haugh

  Roles Conceptualization, Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  * E-mail: jason_haugh@ncsu.edu

  Affiliation Department of Chemical and Biomolecular Engineering, North Carolina State University, Raleigh, North Carolina, United States of America

  http://orcid.org/0000-0002-2476-4027

  ⨯