Individualized genetic network analysis reveals new therapeutic vulnerabilities in 6,700 cancer genomes

• Chuang Liu ,

  Contributed equally to this work with: Chuang Liu, Junfei Zhao, Weiqiang Lu

  Roles Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft

  Affiliation Alibaba Research Center for Complexity Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China

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• Junfei Zhao ,

  Contributed equally to this work with: Chuang Liu, Junfei Zhao, Weiqiang Lu

  Roles Data curation, Formal analysis, Investigation, Visualization, Writing – original draft

  Affiliations Department of Systems Biology, Columbia University, New York, New York, United States of America, Department of Biomedical Informatics, Columbia University, New York, New York, United States of America

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• Weiqiang Lu ,

  Contributed equally to this work with: Chuang Liu, Junfei Zhao, Weiqiang Lu

  Roles Formal analysis, Investigation, Validation, Writing – original draft

  Affiliation Shanghai Key Laboratory of Regulatory Biology, Institute of Biomedical Sciences and School of Life Sciences, East China Normal University, Shanghai, China

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• Yao Dai,

  Roles Formal analysis

  Affiliation Alibaba Research Center for Complexity Sciences, Hangzhou Normal University, Hangzhou, Zhejiang, China

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• Jennifer Hockings,

  Roles Formal analysis

  Affiliation Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

  http://orcid.org/0000-0001-9864-205X

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• Yadi Zhou,

  Roles Formal analysis

  Affiliation Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America

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• Ruth Nussinov,

  Roles Formal analysis, Validation, Writing – review & editing

  Affiliations Cancer and Inflammation Program, Leidos Biomedical Research, Inc., Frederick National Laboratory for Cancer Research, National Cancer Institute at Frederick, Frederick, Maryland, United States of America, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

  http://orcid.org/0000-0002-8115-6415

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• Charis Eng,

  Roles Funding acquisition, Validation, Writing – review & editing

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America, Taussig Cancer Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Genetics and Genome Sciences, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

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• Feixiong Cheng

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Writing – original draft, Writing – review & editing

  * E-mail: chengf@ccf.org

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America, Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

  http://orcid.org/0000-0002-1736-2847

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