Contrasting model mechanisms of alanine aminotransferase (ALT) release from damaged and necrotic hepatocytes as an example of general biomarker mechanisms

• Andrew K. Smith,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0001-6848-0192

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• Glen E. P. Ropella,

  Roles Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Tempus Dictum, Inc., Milwaukie, Oregon, United States of America

  http://orcid.org/0000-0002-6031-105X

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• Mitchell R. McGill,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  Affiliation Department of Environmental and Occupational Health, Fay W. Boozman College of Public Health, University of Arkansas for Medical Sciences, Little Rock, Arkansas, United States of America

  http://orcid.org/0000-0002-0401-0463

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• Preethi Krishnan,

  Roles Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

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• Lopamudra Dutta,

  Roles Formal analysis, Investigation, Project administration, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0003-0219-8586

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• Ryan C. Kennedy,

  Roles Investigation, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0003-2146-4026

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• Hartmut Jaeschke,

  Roles Funding acquisition, Methodology, Writing – review & editing

  Affiliation Department of Pharmacology, Toxicology and Therapeutics, University of Kansas Medical Center, Kansas City, Kansas, United States of America

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• C. Anthony Hunt

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: a.hunt@ucsf.edu

  Affiliation Department of Bioengineering and Therapeutic Sciences, University of California, San Francisco, California, United States of America

  http://orcid.org/0000-0001-9372-6860

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