DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning

• Janine Arloth ,

  Contributed equally to this work with: Janine Arloth, Gökcen Eraslan

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany, Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany

  http://orcid.org/0000-0003-3825-4279

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• Gökcen Eraslan ,

  Contributed equally to this work with: Janine Arloth, Gökcen Eraslan

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft

  Affiliation Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany

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• Till F. M. Andlauer,

  Roles Formal analysis, Funding acquisition, Writing – original draft, Writing – review & editing

  Affiliations Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany, Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany, German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

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• Jade Martins,

  Roles Formal analysis

  Affiliation Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany

  http://orcid.org/0000-0001-6528-8947

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• Stella Iurato,

  Roles Formal analysis

  Affiliation Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany

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• Brigitte Kühnel,

  Roles Formal analysis

  Affiliations Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• Melanie Waldenberger,

  Roles Formal analysis

  Affiliations Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, German Centre for Cardiovascular Research (DZHK), Berlin, Germany

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• Josef Frank,

  Roles Formal analysis

  Affiliation Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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• Ralf Gold,

  Roles Funding acquisition

  Affiliations German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany

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• Bernhard Hemmer,

  Roles Funding acquisition

  Affiliations Department of Neurology, Klinikum rechts der Isar, School of Medicine, Technical University of Munich, Munich, Germany, German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany

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• Felix Luessi,

  Roles Funding acquisition

  Affiliations German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, Department of Neurology, University Medicine Mainz, Johannes Gutenberg University Mainz, Mainz, Germany

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• Sandra Nischwitz,

  Roles Funding acquisition

  Affiliations Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany, German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany

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• Friedemann Paul,

  Roles Funding acquisition

  Affiliations German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, NeuroCure Clinical Research Center, Department of Neurology, and Experimental and Clinical Research Center, Max Delbrück Center for Molecular Medicine, and Charitϩ –Universitätsmedizin Berlin, Berlin, Germany

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• Heinz Wiendl,

  Roles Funding acquisition

  Affiliations German Competence Network Multiple Sclerosis (KKNMS), Klinikum rechts der Isar, Technical University of Munich, Munich, Germany, Department of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany

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• Christian Gieger,

  Roles Funding acquisition

  Affiliations Research Unit of Molecular Epidemiology and Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany, Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• Stefanie Heilmann-Heimbach,

  Roles Funding acquisition

  Affiliation Institute of Human Genetics, University Hospital Bonn and Division of Genomics, Life & Brain Research Centre, University of Bonn School of Medicine, Bonn, Germany

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• Tim Kacprowski,

  Roles Funding acquisition

  Affiliations Interfaculty Institute for Genetics and Functional Genomics, University Medicine and University of Greifswald, Greifswald, Germany, Junior Research Group on Computational Systems Medicine, Chair of Experimental Bioinformatics, TUM School of Life Sciences Weihenstephan, Technical University of Munich, Freising-Weihenstephan, Germany

  http://orcid.org/0000-0002-5393-2413

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• Matthias Laudes,

  Roles Funding acquisition

  Affiliation Department I of Internal Medicine, Kiel University, Kiel, Germany

  ⨯
• Thomas Meitinger,

  Roles Funding acquisition

  Affiliation Institute of Human Genetics, Helmholtz Zentrum München, Neuherberg, Germany and Institute of Human Genetics, Technical University of Munich, Munich, Germany

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• Annette Peters,

  Roles Funding acquisition

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

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• Rajesh Rawal,

  Roles Funding acquisition

  Affiliation Institute of Epidemiology and Social Medicine, University of Münster, Münster, Germany

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• Konstantin Strauch,

  Roles Funding acquisition

  Affiliation Institute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany and Institute of Medical Informatics, Biometry, and Epidemiology, Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany

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• Susanne Lucae,

  Roles Funding acquisition

  Affiliation Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany

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• Bertram Müller-Myhsok,

  Roles Funding acquisition

  Affiliations Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany, Munich Cluster for Systems Neurology (SyNergy), Munich, Germany, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom

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• Marcella Rietschel,

  Roles Funding acquisition

  Affiliation Institute of Epidemiology, Helmholtz Zentrum München, Neuherberg, Germany

  http://orcid.org/0000-0002-5236-6149

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• Fabian J. Theis,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany, Department of Mathematics, Technical University of Munich, Garching, Germany

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• Elisabeth B. Binder,

  Roles Funding acquisition, Supervision, Writing – review & editing

  Affiliations Department of Translational Research in Psychiatry, Max Planck Institute of Psychiatry, Munich, Germany, Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta GA, United States of America

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•  [ ... ],
• Nikola S. Mueller

  Roles Conceptualization, Funding acquisition, Investigation, Project administration, Supervision, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: nikola.mueller@helmholtz-muenchen.de

  Affiliation Institute of Computational Biology, Helmholtz Zentrum München, Neuherberg, Germany

  http://orcid.org/0000-0001-8659-4548

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