Adaptive landscape flattening allows the design of both enzyme: Substrate binding and catalytic power

• Vaitea Opuu,

  Roles Formal analysis, Investigation, Methodology, Software

  Affiliation Laboratoire de Biochimie (CNRS UMR7654), Ecole Polytechnique, Palaiseau, France

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• Giuliano Nigro,

  Roles Investigation

  Affiliation Laboratoire de Biochimie (CNRS UMR7654), Ecole Polytechnique, Palaiseau, France

  http://orcid.org/0000-0003-3458-9952

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• Thomas Gaillard,

  Roles Investigation

  Affiliation Laboratoire de Biochimie (CNRS UMR7654), Ecole Polytechnique, Palaiseau, France

  http://orcid.org/0000-0002-5224-546X

  ⨯
• Emmanuelle Schmitt,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Laboratoire de Biochimie (CNRS UMR7654), Ecole Polytechnique, Palaiseau, France

  ⨯
• Yves Mechulam,

  Roles Conceptualization, Data curation, Investigation, Methodology, Project administration, Supervision, Writing – review & editing

  Affiliation Laboratoire de Biochimie (CNRS UMR7654), Ecole Polytechnique, Palaiseau, France

  http://orcid.org/0000-0003-3586-3554

  ⨯
• Thomas Simonson

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Software, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: thomas.simonson@polytechnique.fr

  Affiliation Laboratoire de Biochimie (CNRS UMR7654), Ecole Polytechnique, Palaiseau, France

  http://orcid.org/0000-0002-5117-7338

  ⨯