Leveraging effect size distributions to improve polygenic risk scores derived from summary statistics of genome-wide association studies

• Shuang Song ,

  Contributed equally to this work with: Shuang Song, Wei Jiang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Center for Statistical Science, Tsinghua University, Beijing, China, Department of Industrial Engineering, Tsinghua University, Beijing, China

  http://orcid.org/0000-0002-1903-090X

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• Wei Jiang ,

  Contributed equally to this work with: Shuang Song, Wei Jiang

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Department of Biostatistics, School of Public Health, Yale University, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0001-6120-5278

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• Lin Hou,

  Roles Investigation, Validation, Writing – review & editing

  Affiliations Center for Statistical Science, Tsinghua University, Beijing, China, Department of Industrial Engineering, Tsinghua University, Beijing, China

  http://orcid.org/0000-0002-4283-8501

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• Hongyu Zhao

  Roles Conceptualization, Formal analysis, Funding acquisition, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: hongyu.zhao@yale.edu

  Affiliation Department of Biostatistics, School of Public Health, Yale University, New Haven, Connecticut, United States of America

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