Heterogeneous responses to low level death receptor activation are explained by random molecular assembly of the Caspase-8 activation platform

• Anna Matveeva,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

  http://orcid.org/0000-0001-9997-1955

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• Michael Fichtner ,

  Contributed equally to this work with: Michael Fichtner, Katherine McAllister

  Roles Data curation, Formal analysis, Investigation

  Affiliations Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

  http://orcid.org/0000-0002-5640-7454

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• Katherine McAllister ,

  Contributed equally to this work with: Michael Fichtner, Katherine McAllister

  Roles Data curation, Formal analysis, Investigation

  Affiliation Centre for Cancer Research and Cell Biology, Queen’s University, Belfast, United Kingdom

  http://orcid.org/0000-0002-2893-7706

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• Christopher McCann,

  Roles Data curation, Formal analysis, Investigation

  Affiliation Centre for Cancer Research and Cell Biology, Queen’s University, Belfast, United Kingdom

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• Marc Sturrock,

  Roles Methodology, Writing – review & editing

  Affiliations Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

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• Daniel B. Longley,

  Roles Data curation, Funding acquisition, Writing – review & editing

  Affiliation Centre for Cancer Research and Cell Biology, Queen’s University, Belfast, United Kingdom

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• Jochen H. M. Prehn

  Roles Conceptualization, Data curation, Funding acquisition, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: prehn@rcsi.ie

  Affiliations Centre for Systems Medicine, Royal College of Surgeons in Ireland, Dublin, Ireland, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland

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