Weak coupling between intracellular feedback loops explains dissociation of clock gene dynamics

• Christoph Schmal ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Visualization, Writing – original draft

  * E-mail: christoph.schmal@charite.de (CS); isao@fc.ritsumei.ac.jp (ITT)

  Affiliations Department of Mechanical Engineering, Ritsumeikan University, Kusatsu, Japan, Institute for Theoretical Biology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Institute for Theoretical Biology, Humboldt Universität zu Berlin, Berlin, Germany

  http://orcid.org/0000-0002-9213-3868

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• Daisuke Ono,

  Roles Conceptualization, Data curation

  Affiliation Department of Neuroscience II, Research Institute of Environmental Medicine, Nagoya University, Nagoya, Japan

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• Jihwan Myung,

  Roles Conceptualization, Writing – review & editing

  Affiliations Laboratory of Braintime, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, Graduate Institute of Mind, Brain, and Consciousness, Taipei Medical University, Taipei, Taiwan, Graduate Institute of Medical Sciences, Taipei Medical University, Taipei, Taiwan, TMU Research Center of Brain and Consciousness, Shuang Ho Hospital, Taipei Medical University, New Taipei City, Taiwan, Computational Neuroscience Unit, Okinawa Institute of Science and Technology, Okinawa, Japan

  http://orcid.org/0000-0002-2529-8013

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• J. Patrick Pett,

  Roles Formal analysis, Methodology, Writing – original draft

  Affiliations Institute for Theoretical Biology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Institute for Theoretical Biology, Humboldt Universität zu Berlin, Berlin, Germany

  http://orcid.org/0000-0002-5249-444X

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• Sato Honma,

  Roles Conceptualization, Supervision

  Affiliation Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

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• Ken-Ichi Honma,

  Roles Conceptualization, Supervision

  Affiliation Department of Chronomedicine, Hokkaido University Graduate School of Medicine, Sapporo, Japan

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• Hanspeter Herzel,

  Roles Conceptualization, Resources, Writing – review & editing

  Affiliations Institute for Theoretical Biology, Charité - Universitätsmedizin Berlin, Berlin, Germany, Institute for Theoretical Biology, Humboldt Universität zu Berlin, Berlin, Germany

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• Isao T. Tokuda

  Roles Conceptualization, Project administration, Resources, Supervision, Writing – original draft

  * E-mail: christoph.schmal@charite.de (CS); isao@fc.ritsumei.ac.jp (ITT)

  Affiliation Department of Mechanical Engineering, Ritsumeikan University, Kusatsu, Japan

  http://orcid.org/0000-0001-6212-0022

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