Estimating the number of genetic mutations (hits) required for carcinogenesis based on the distribution of somatic mutations

• Ramu Anandakrishnan ,

  Roles Conceptualization, Data curation, Formal analysis, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: ramu@vt.edu

  Affiliations Gibbs Cancer Center and Research Institute, Spartanburg, SC, United States of America, Department of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States of America

  http://orcid.org/0000-0003-0422-3984

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• Robin T. Varghese,

  Roles Data curation, Validation, Writing – review & editing

  Affiliations Gibbs Cancer Center and Research Institute, Spartanburg, SC, United States of America, Department of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States of America

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• Nicholas A. Kinney,

  Roles Formal analysis, Methodology, Software, Validation, Writing – review & editing

  Affiliations Gibbs Cancer Center and Research Institute, Spartanburg, SC, United States of America, Department of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States of America

  http://orcid.org/0000-0002-4563-1813

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• Harold R. Garner

  Roles Formal analysis, Funding acquisition, Project administration, Resources, Supervision, Validation, Writing – review & editing

  Affiliations Gibbs Cancer Center and Research Institute, Spartanburg, SC, United States of America, Department of Biomedical Sciences, Edward Via College of Osteopathic Medicine, Blacksburg, VA, United States of America

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