OptRAM: In-silico strain design via integrative regulatory-metabolic network modeling

• Fangzhou Shen,

  Roles Data curation, Formal analysis, Methodology, Validation, Writing – original draft

  Affiliations Bio-X Institutes, Key laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China, Department of Biomedical Engineering, University of Michigan, Ann Arbor, Michigan, United States of America

  ⨯
• Renliang Sun,

  Roles Data curation, Visualization

  Affiliations Bio-X Institutes, Key laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

  ⨯
• Jie Yao,

  Roles Methodology, Validation, Visualization

  Affiliation School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

  ⨯
• Jian Li,

  Roles Formal analysis, Methodology, Validation

  Affiliations Bio-X Institutes, Key laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

  ⨯
• Qian Liu,

  Roles Validation

  Affiliation School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

  ⨯
• Nathan D. Price,

  Roles Conceptualization, Funding acquisition, Writing – review & editing

  Affiliation Institute for Systems Biology, Seattle, Washington, United States of America

  ⨯
• Chenguang Liu,

  Roles Validation, Writing – review & editing

  Affiliation School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

  http://orcid.org/0000-0003-0343-6304

  ⨯
• Zhuo Wang

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: zhuowang@sjtu.edu.cn

  Affiliations Bio-X Institutes, Key laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China

  http://orcid.org/0000-0002-6382-1717

  ⨯