Network-guided prediction of aromatase inhibitor response in breast cancer

Matthew Ruffalo; Roby Thomas; Jian Chen; Adrian V. Lee; Steffi Oesterreich; Ziv Bar-Joseph

doi:10.1371/journal.pcbi.1006730

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Open Access

Peer-reviewed

Research Article

Network-guided prediction of aromatase inhibitor response in breast cancer

Matthew Ruffalo,

Roles Conceptualization, Data curation, Investigation, Methodology, Validation, Visualization, Writing – original draft, Writing – review & editing

Affiliation Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0003-2222-6169

⨯
Roby Thomas,

Roles Conceptualization, Data curation, Writing – review & editing

Affiliation Women’s Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0003-4828-4586

⨯
Jian Chen,

Roles Data curation, Methodology, Validation

Affiliation Women’s Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Adrian V. Lee,

Roles Conceptualization, Methodology, Validation, Writing – review & editing

Affiliation Women’s Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Steffi Oesterreich,

Roles Conceptualization, Investigation, Resources, Validation, Writing – review & editing

Affiliation Women’s Cancer Research Center, Department of Pharmacology and Chemical Biology, UPMC Hillman Cancer Center, Magee Womens Research Institute, Pittsburgh, Pennsylvania, United States of America
⨯
Ziv Bar-Joseph

Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing

* E-mail: zivbj@cs.cmu.edu

Affiliations Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America, Machine Learning Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, Pennsylvania, United States of America

http://orcid.org/0000-0003-3430-6051

⨯

Network-guided prediction of aromatase inhibitor response in breast cancer

Matthew Ruffalo,
Roby Thomas,
Jian Chen,
Adrian V. Lee,
Steffi Oesterreich,
Ziv Bar-Joseph

Published: February 11, 2019
https://doi.org/10.1371/journal.pcbi.1006730

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Breast cancer
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Cancer treatment
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Aromatase inhibitors
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Estrogens
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Gene expression
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Cancers and neoplasms
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Protein interaction networks
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Cancer genomics
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