Dynamic filopodial forces induce accumulation, damage, and plastic remodeling of 3D extracellular matrices

• Andrea Malandrino ,

  Contributed equally to this work with: Andrea Malandrino, Michael Mak

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Writing – original draft, Writing – review & editing

  * E-mail: andrea.malandrino@embl.es (AM); rdkamm@mit.edu (RDK); Michael.Mak@Yale.edu (MM)

  Current address: European Molecular Biology Laboratory, Barcelona, Spain

  Affiliations Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Institute for Bioengineering of Catalonia, Barcelona, Spain

  http://orcid.org/0000-0002-7928-0951

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• Xavier Trepat,

  Roles Resources, Supervision

  Affiliations Institute for Bioengineering of Catalonia, Barcelona, Spain, Unitat de Biofísica i Bioenginyeria, Facultat de Medicina, Universitat de Barcelona, Barcelona, Spain, Institució Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Spain, Centro de Investigación Biomédica en Red en Bioingeniería, Biomateriales y Nanomedicina, Madrid, Spain

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• Roger D. Kamm ,

  Roles Conceptualization, Formal analysis, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: andrea.malandrino@embl.es (AM); rdkamm@mit.edu (RDK); Michael.Mak@Yale.edu (MM)

  Affiliations Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America, Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, United States of America

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• Michael Mak

  Contributed equally to this work with: Andrea Malandrino, Michael Mak

  Roles Conceptualization, Formal analysis, Funding acquisition, Investigation, Methodology, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: andrea.malandrino@embl.es (AM); rdkamm@mit.edu (RDK); Michael.Mak@Yale.edu (MM)

  Affiliation Yale University, Biomedical Engineering Department, New Haven, Connecticut, United States of America

  http://orcid.org/0000-0001-6881-8130

  ⨯