Review: Precision medicine and driver mutations: Computational methods, functional assays and conformational principles for interpreting cancer drivers

• Ruth Nussinov ,

  * E-mail: NussinoR@mail.nih.gov

  Affiliations Computational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America, Department of Human Molecular Genetics and Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

  http://orcid.org/0000-0002-8115-6415

  ⨯
• Hyunbum Jang,

  Affiliation Computational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

  ⨯
• Chung-Jung Tsai,

  Affiliation Computational Structural Biology Section, Basic Science Program, Frederick National Laboratory for Cancer Research, National Cancer Institute, Frederick, Maryland, United States of America

  ⨯
• Feixiong Cheng

  Affiliations Genomic Medicine Institute, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, United States of America, Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine, Case Western Reserve University, Cleveland, Ohio, United States of America

  http://orcid.org/0000-0002-1736-2847

  ⨯