Network-level allosteric effects are elucidated by detailing how ligand-binding events modulate utilization of catalytic potentials

• James T. Yurkovich ,

  Contributed equally to this work with: James T. Yurkovich, Miguel A. Alcantar

  Roles Conceptualization, Formal analysis, Writing – original draft, Writing – review & editing

  Affiliations Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA, Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA

  http://orcid.org/0000-0002-9403-509X

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• Miguel A. Alcantar ,

  Contributed equally to this work with: James T. Yurkovich, Miguel A. Alcantar

  Roles Formal analysis, Writing – original draft, Writing – review & editing

  Affiliation Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA

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• Zachary B. Haiman,

  Roles Formal analysis, Writing – review & editing

  Affiliation Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA

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• Bernhard O. Palsson

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  * E-mail: palsson@ucsd.edu

  Affiliations Department of Bioengineering, University of California, San Diego, La Jolla, CA, USA, Bioinformatics and Systems Biology Program, University of California, San Diego, La Jolla, CA, USA, Department of Pediatrics, University of California, San Diego, La Jolla, CA, USA

  http://orcid.org/0000-0003-2357-6785

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