A local uPAR-plasmin-TGFβ1 positive feedback loop in a qualitative computational model of angiogenic sprouting explains the in vitro effect of fibrinogen variants

• Sonja E. M. Boas ,

  Contributed equally to this work with: Sonja E. M. Boas, Joao Carvalho

  Roles Conceptualization, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft

  Affiliations Centrum Wiskunde & Informatica (CWI), Amsterdam, The Netherlands, Mathematical Institute, Leiden University, Leiden, The Netherlands

  http://orcid.org/0000-0001-9413-7013

  ⨯
• Joao Carvalho ,

  Contributed equally to this work with: Sonja E. M. Boas, Joao Carvalho

  Roles Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

  Affiliations Centrum Wiskunde & Informatica (CWI), Amsterdam, The Netherlands, CFisUC, Department of Physics, University of Coimbra, Coimbra, Portugal

  http://orcid.org/0000-0001-9955-4131

  ⨯
• Marloes van den Broek,

  Roles Investigation, Methodology, Validation

  Affiliation Amsterdam Cardiovascular Sciences, VU University medical Center, Dept. of Physiology, Amsterdam, The Netherlands

  ⨯
• Ester M. Weijers,

  Roles Conceptualization, Methodology, Supervision, Validation

  Affiliation Amsterdam Cardiovascular Sciences, VU University medical Center, Dept. of Physiology, Amsterdam, The Netherlands

  http://orcid.org/0000-0002-6417-2026

  ⨯
• Marie-José Goumans,

  Roles Conceptualization, Validation, Writing – review & editing

  Affiliation Department of Cell and Chemical Biology, Leiden University Medical Center, Leiden, The Netherlands

  http://orcid.org/0000-0001-9344-6746

  ⨯
• Pieter Koolwijk,

  Roles Conceptualization, Supervision, Validation, Writing – review & editing

  Affiliation Amsterdam Cardiovascular Sciences, VU University medical Center, Dept. of Physiology, Amsterdam, The Netherlands

  ⨯
• Roeland M. H. Merks

  Roles Conceptualization, Funding acquisition, Investigation, Methodology, Project administration, Supervision, Validation, Writing – review & editing

  * E-mail: merksrmh@math.leidenuniv.nl

  Current address: Mathematical Institute and Institute for Biology Leiden, Leiden University, Leiden, The Netherlands

  Affiliations Centrum Wiskunde & Informatica (CWI), Amsterdam, The Netherlands, Mathematical Institute, Leiden University, Leiden, The Netherlands

  http://orcid.org/0000-0002-6152-687X

  ⨯