Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening

Daniel Jimenez-Carretero; Vahid Abrishami; Laura Fernández-de-Manuel; Irene Palacios; Antonio Quílez-Álvarez; Alberto Díez-Sánchez; Miguel A. del Pozo; María C. Montoya

doi:10.1371/journal.pcbi.1006238

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Open Access

Peer-reviewed

Research Article

Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening

Daniel Jimenez-Carretero ,

Contributed equally to this work with: Daniel Jimenez-Carretero, Vahid Abrishami

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Cellomics Unit, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Vahid Abrishami ,

Contributed equally to this work with: Daniel Jimenez-Carretero, Vahid Abrishami

Roles Formal analysis, Investigation, Methodology, Software, Writing – review & editing

Affiliation Cellomics Unit, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Laura Fernández-de-Manuel,

Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – review & editing

Affiliation Cellomics Unit, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Irene Palacios,

Roles Investigation

Affiliation Cellomics Unit, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Antonio Quílez-Álvarez,

Roles Investigation

Affiliation Cellomics Unit, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
Alberto Díez-Sánchez,

Roles Investigation

Affiliation Mechanoadaptation and Caveolae biology, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

http://orcid.org/0000-0001-5146-3089

⨯
Miguel A. del Pozo,

Roles Funding acquisition, Resources, Writing – review & editing

Affiliation Mechanoadaptation and Caveolae biology, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain
⨯
María C. Montoya

Roles Conceptualization, Funding acquisition, Methodology, Project administration, Software, Supervision, Writing – original draft

* E-mail: mmontoya@cnic.es

Affiliation Cellomics Unit, Cell & Developmental Biology Area, Centro Nacional de Investigaciones Cardiovasculares (CNIC), Madrid, Spain

http://orcid.org/0000-0001-8878-7028

⨯

Tox_(R)CNN: Deep learning-based nuclei profiling tool for drug toxicity screening

Daniel Jimenez-Carretero,
Vahid Abrishami,
Laura Fernández-de-Manuel,
Irene Palacios,
Antonio Quílez-Álvarez,
Alberto Díez-Sánchez,
Miguel A. del Pozo,
María C. Montoya

Published: November 30, 2018
https://doi.org/10.1371/journal.pcbi.1006238
See the preprint

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Toxicity
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Nuclear staining
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