Integrative single-cell omics analyses reveal epigenetic heterogeneity in mouse embryonic stem cells

• Yanting Luo ,

  Contributed equally to this work with: Yanting Luo, Jianlin He

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China, University of Chinese Academy of Sciences, Beijing, China

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• Jianlin He ,

  Contributed equally to this work with: Yanting Luo, Jianlin He

  Roles Data curation, Formal analysis, Investigation, Methodology, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, University of Chinese Academy of Sciences, Beijing, China, Epigenomics and Computational Biology Lab, Biocomplexity Institute of Virginia Tech, Blacksburg, United States of America

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• Xiguang Xu,

  Roles Investigation, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  Affiliations Epigenomics and Computational Biology Lab, Biocomplexity Institute of Virginia Tech, Blacksburg, United States of America, Department of Biological Sciences, Virginia Tech, Blacksburg, United States of America

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• Ming-an Sun,

  Roles Investigation, Writing – review & editing

  Affiliation University of Chinese Academy of Sciences, Beijing, China

  http://orcid.org/0000-0002-4661-3027

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• Xiaowei Wu,

  Roles Writing – review & editing

  Affiliation Department of Statistics, Virginia Tech, Blacksburg, United States of America

  http://orcid.org/0000-0001-9916-3624

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• Xuemei Lu ,

  Roles Funding acquisition, Project administration, Resources, Writing – original draft, Writing – review & editing

  * E-mail: luxm@big.ac.cn (XL); davidxie@vt.edu (HX)

  Affiliations Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing, China, CAS Center for Excellence in Animal Evolution and Genetics, Chinese Academy of Sciences, Kunming, China, University of Chinese Academy of Sciences, Beijing, China

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• Hehuang Xie

  Roles Conceptualization, Funding acquisition, Project administration, Resources, Supervision, Writing – original draft, Writing – review & editing

  * E-mail: luxm@big.ac.cn (XL); davidxie@vt.edu (HX)

  Affiliations Epigenomics and Computational Biology Lab, Biocomplexity Institute of Virginia Tech, Blacksburg, United States of America, Department of Biological Sciences, Virginia Tech, Blacksburg, United States of America, Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Tech, Blacksburg, United States of America

  http://orcid.org/0000-0001-5739-1653

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