A computational approach to distinguish somatic vs. germline origin of genomic alterations from deep sequencing of cancer specimens without a matched normal

• James X. Sun ,

  Roles Conceptualization, Data curation, Formal analysis, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: jsun@foundationmedicine.com

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

  http://orcid.org/0000-0003-0475-9391

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• Yuting He,

  Roles Data curation, Formal analysis, Software, Validation, Writing – original draft, Writing – review & editing

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

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• Eric Sanford,

  Roles Data curation, Formal analysis, Validation, Writing – original draft

  Current address: Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, United States of America.

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

  http://orcid.org/0000-0002-9232-9334

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• Meagan Montesion,

  Roles Writing – review & editing

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

  http://orcid.org/0000-0001-9155-556X

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• Garrett M. Frampton,

  Roles Conceptualization, Writing – original draft, Writing – review & editing

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

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• Stéphane Vignot,

  Roles Resources

  Affiliations Institut National de la Santé et de la Recherche Médicale (INSERM) U981, Gustave Roussy, Villejuif Grand, Paris, France, Oncology and Hematology Department, Hôpitaux de Chartres, Chartres, France

  http://orcid.org/0000-0002-1292-6631

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• Jean-Charles Soria,

  Roles Resources

  Affiliation Institut National de la Santé et de la Recherche Médicale (INSERM) U981, Gustave Roussy, Villejuif Grand, Paris, France

  ⨯
• Jeffrey S. Ross,

  Roles Data curation, Supervision

  Affiliations Foundation Medicine, Inc., Cambridge, MA, United States of America, Albany Medical College, Albany, NY, United States of America

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• Vincent A. Miller,

  Roles Supervision

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

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• Phil J. Stephens,

  Roles Supervision

  Current address: GRAIL, Menlo Park, CA, United States of America.

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

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• Doron Lipson,

  Roles Project administration, Supervision

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

  ⨯
• Roman Yelensky

  Roles Conceptualization, Formal analysis, Methodology, Supervision, Writing – original draft, Writing – review & editing

  Current address: Gritstone Oncology, Cambridge, MA, United States of America.

  Affiliation Foundation Medicine, Inc., Cambridge, MA, United States of America

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