Machine learning to design integral membrane channelrhodopsins for efficient eukaryotic expression and plasma membrane localization

• Claire N. Bedbrook ,

  Contributed equally to this work with: Claire N. Bedbrook, Kevin K. Yang

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Biology and Biological Engineering; California Institute of Technology; Pasadena, California; United States of America

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• Kevin K. Yang ,

  Contributed equally to this work with: Claire N. Bedbrook, Kevin K. Yang

  Roles Conceptualization, Formal analysis, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

  Affiliation Division of Chemistry and Chemical Engineering; California Institute of Technology; Pasadena, California; United States of America

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• Austin J. Rice,

  Roles Conceptualization, Methodology, Visualization, Writing – review & editing

  Affiliation Division of Chemistry and Chemical Engineering; California Institute of Technology; Pasadena, California; United States of America

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• Viviana Gradinaru,

  Roles Conceptualization, Supervision, Writing – review & editing

  Affiliation Division of Biology and Biological Engineering; California Institute of Technology; Pasadena, California; United States of America

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• Frances H. Arnold

  Roles Conceptualization, Project administration, Supervision, Writing – review & editing

  * E-mail: fha@cheme.caltech.edu

  Affiliations Division of Biology and Biological Engineering; California Institute of Technology; Pasadena, California; United States of America, Division of Chemistry and Chemical Engineering; California Institute of Technology; Pasadena, California; United States of America

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