A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

Chiara Damiani; Riccardo Colombo; Daniela Gaglio; Fabrizia Mastroianni; Dario Pescini; Hans Victor Westerhoff; Giancarlo Mauri; Marco Vanoni; Lilia Alberghina

doi:10.1371/journal.pcbi.1005758

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Open Access

Peer-reviewed

Research Article

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

Chiara Damiani,

Roles Investigation, Methodology, Software, Visualization, Writing – original draft, Writing – review & editing

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Dept of Informatics, Systems and Communication, University Milano-Bicocca, Milano, Italy
⨯
Riccardo Colombo,

Roles Software, Visualization

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Dept of Informatics, Systems and Communication, University Milano-Bicocca, Milano, Italy
⨯
Daniela Gaglio,

Roles Investigation

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Institute of Molecular Bioimaging and Physiology, CNR, Segrate, Milan, Italy
⨯
Fabrizia Mastroianni,

Roles Investigation

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Dept of Biotechnology and Biosciences, University Milano-Bicocca, Milano, Italy
⨯
Dario Pescini,

Roles Software, Visualization

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Dept of Statistics and Quantitative Methods, University Milano-Bicocca, Milano, Italy

http://orcid.org/0000-0002-3090-4823

⨯
Hans Victor Westerhoff,

Roles Methodology, Writing – original draft, Writing – review & editing

Affiliations Dept of Molecular Cell Physiology, Faculty of Earth and Life Sciences, VU University, Amsterdam, The Netherlands, Manchester Centre for Integrative Systems Biology, School of Chemical Engineering and Analytical Science, University of Manchester, Manchester, United Kingdom, Swammerdam Institute for Life Sciences, Faculty of Science, University of Amsterdam, Amsterdam, The Netherlands
⨯
Giancarlo Mauri,

Roles Software

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Dept of Informatics, Systems and Communication, University Milano-Bicocca, Milano, Italy

http://orcid.org/0000-0003-3520-4022

⨯
Marco Vanoni ,

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: lilia.alberghina@unimib.it (LA); marco.vanoni@unimib.it (MV)

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Dept of Biotechnology and Biosciences, University Milano-Bicocca, Milano, Italy
⨯
Lilia Alberghina

Roles Conceptualization, Writing – original draft, Writing – review & editing

* E-mail: lilia.alberghina@unimib.it (LA); marco.vanoni@unimib.it (MV)

Affiliations SYSBIO Centre of Systems Biology, Milano, Italy, Dept of Biotechnology and Biosciences, University Milano-Bicocca, Milano, Italy
⨯

A metabolic core model elucidates how enhanced utilization of glucose and glutamine, with enhanced glutamine-dependent lactate production, promotes cancer cell growth: The WarburQ effect

Chiara Damiani,
Riccardo Colombo,
Daniela Gaglio,
Fabrizia Mastroianni,
Dario Pescini,
Hans Victor Westerhoff,
Giancarlo Mauri,
Marco Vanoni,
Lilia Alberghina

Published: September 28, 2017
https://doi.org/10.1371/journal.pcbi.1005758

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Glutamine
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Glucose
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