Deciphering HLA-I motifs across HLA peptidomes improves neo-antigen predictions and identifies allostery regulating HLA specificity

• Michal Bassani-Sternberg ,

  Roles Conceptualization, Formal analysis, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing

  * E-mail: David.Gfeller@unil.ch (DG); Michal.Bassani@chuv.ch (MBS)

  ¶‡ These authors share first authorship on this work.

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland

  http://orcid.org/0000-0002-1934-954X

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• Chloé Chong,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland

  ⨯
• Philippe Guillaume,

  Roles Formal analysis, Investigation, Methodology, Resources

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland

  ⨯
• Marthe Solleder,

  Roles Formal analysis, Investigation, Methodology

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  ⨯
• HuiSong Pak,

  Roles Investigation, Methodology

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland

  ⨯
• Philippe O. Gannon,

  Roles Resources

  Affiliation Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland

  http://orcid.org/0000-0003-3263-3999

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• Lana E. Kandalaft,

  Roles Resources

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland

  ⨯
• George Coukos,

  Roles Funding acquisition, Resources

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland

  ⨯
• David Gfeller

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Supervision, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: David.Gfeller@unil.ch (DG); Michal.Bassani@chuv.ch (MBS)

  ¶‡ These authors share first authorship on this work.

  Affiliations Ludwig Centre for Cancer Research, University of Lausanne, Epalinges, Switzerland, Department of Fundamental Oncology, University Hospital of Lausanne, Lausanne, Switzerland, Swiss Institute of Bioinformatics (SIB), Lausanne, Switzerland

  http://orcid.org/0000-0002-3952-0930

  ⨯