A computational model of spatio-temporal cardiac intracellular calcium handling with realistic structure and spatial flux distribution from sarcoplasmic reticulum and t-tubule reconstructions

• Michael A. Colman ,

  Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Software, Validation, Visualization, Writing – original draft, Writing – review & editing

  * E-mail: m.a.colman@leeds.ac.uk

  Affiliations School of Biomedical Sciences, Faculty of Biological Sciences, University of Leeds, Leeds, United Kingdom, School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0003-2817-8508

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• Christian Pinali,

  Roles Investigation, Writing – review & editing

  Affiliation Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health Sciences, University of Manchester, Manchester, United Kingdom

  http://orcid.org/0000-0001-9815-6940

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• Andrew W. Trafford,

  Roles Resources, Writing – review & editing

  Affiliation Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health Sciences, University of Manchester, Manchester, United Kingdom

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• Henggui Zhang,

  Roles Conceptualization, Writing – review & editing

  Affiliation School of Physics and Astronomy, Faculty of Engineering and Physical Sciences, University of Manchester, Manchester, United Kingdom

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• Ashraf Kitmitto

  Roles Conceptualization, Data curation, Funding acquisition, Investigation, Resources, Writing – review & editing

  Affiliation Division of Cardiovascular Sciences, Faculty of Biology, Medicine and Health Sciences, University of Manchester, Manchester, United Kingdom

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