Bioenergetics-based modeling of Plasmodium falciparum metabolism reveals its essential genes, nutritional requirements, and thermodynamic bottlenecks

• Anush Chiappino-Pepe,

  Affiliation Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland

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• Stepan Tymoshenko,

  Affiliations Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland, Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CMU, Geneva, Switzerland

  http://orcid.org/0000-0002-7364-7054

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• Meriç Ataman,

  Affiliation Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland

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• Dominique Soldati-Favre,

  Affiliation Department of Microbiology and Molecular Medicine, Faculty of Medicine, University of Geneva, CMU, Geneva, Switzerland

  http://orcid.org/0000-0003-4156-2109

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• Vassily Hatzimanikatis

  * E-mail: vassily.hatzimanikatis@epfl.ch

  Affiliation Laboratory of Computational Systems Biotechnology, École Polytechnique Fédérale de Lausanne, EPFL, Lausanne, Switzerland

  http://orcid.org/0000-0001-6432-4694

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