Cheminformatics-aided discovery of small-molecule Protein-Protein Interaction (PPI) dual inhibitors of Tumor Necrosis Factor (TNF) and Receptor Activator of NF-κB Ligand (RANKL)

• Georgia Melagraki ,

  ¶‡ GM and EN are co-first authors

  Affiliations Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, NovaMechanics Ltd, Nicosia, Cyprus

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• Evangelos Ntougkos ,

  ¶‡ GM and EN are co-first authors

  Affiliation Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece

  http://orcid.org/0000-0001-9805-9710

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• Vagelis Rinotas,

  Affiliations Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens, Greece

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• Christos Papaneophytou,

  Affiliations Veterinary School, University of Thessaly, Karditsa, Greece, Institute for Research and Technology Thessaly (IRETETH), Volos, Greece, Department of Life and Health Sciences, School of Sciences and Engineering, University of Nicosia, Nicosia, Cyprus

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• Georgios Leonis,

  Affiliation NovaMechanics Ltd, Nicosia, Cyprus

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• Thomas Mavromoustakos,

  Affiliation Laboratory of Organic Chemistry, Department of Chemistry, National and Kapodistrian University of Athens, Athens, Greece

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• George Kontopidis,

  Affiliations Veterinary School, University of Thessaly, Karditsa, Greece, Institute for Research and Technology Thessaly (IRETETH), Volos, Greece

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• Eleni Douni,

  Affiliations Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, Laboratory of Genetics, Department of Biotechnology, Agricultural University of Athens, Athens, Greece

  http://orcid.org/0000-0003-0004-5121

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• Antreas Afantitis ,

  * E-mail: afantitis@novamechanics.com (AA); kollias@fleming.gr (GKol)

  Affiliations Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, NovaMechanics Ltd, Nicosia, Cyprus

  http://orcid.org/0000-0002-0977-8180

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• George Kollias

  * E-mail: afantitis@novamechanics.com (AA); kollias@fleming.gr (GKol)

  Affiliations Division of Immunology, Biomedical Sciences Research Center 'Alexander Fleming', Vari, Greece, Department of Experimental Physiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece

  http://orcid.org/0000-0003-1867-3150

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