Optimality principles reveal a complex interplay of intermediate toxicity and kinetic efficiency in the regulation of prokaryotic metabolism

Open Access

Peer-reviewed

Research Article

Jan Ewald,

Affiliation Research Group Theoretical Systems Biology, Department of Bioinformatics, Friedrich-Schiller-Universität Jena, Jena, Germany
⨯
Martin Bartl,

Affiliation Research Group Theoretical Systems Biology, Department of Bioinformatics, Friedrich-Schiller-Universität Jena, Jena, Germany
⨯
Thomas Dandekar,

Affiliation Department of Bioinformatics, Biocenter, Julius-Maximilians-Universität Würzburg, Würzburg, Germany

http://orcid.org/0000-0003-1886-7625

⨯
Christoph Kaleta

* E-mail: c.kaleta@iem.uni-kiel.de

Affiliation Research Group Medical Systems Biology, Christian-Albrechts-Universität zu Kiel, Kiel, Germany
⨯

Reader Comments (0)

Enzyme regulation
Is the Subject Area "Enzyme regulation" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Metabolic pathways
Is the Subject Area "Metabolic pathways" applicable to this article?

Thanks for your feedback.
Enzymes
Is the Subject Area "Enzymes" applicable to this article?

Thanks for your feedback.
Transcriptional control
Is the Subject Area "Transcriptional control" applicable to this article?

Thanks for your feedback.
Enzyme kinetics
Is the Subject Area "Enzyme kinetics" applicable to this article?

Thanks for your feedback.
Enzyme metabolism
Is the Subject Area "Enzyme metabolism" applicable to this article?

Thanks for your feedback.
Predictive toxicology
Is the Subject Area "Predictive toxicology" applicable to this article?

Thanks for your feedback.