Multiscale mutation clustering algorithm identifies pan-cancer mutational clusters associated with pathway-level changes in gene expression

Open Access

Peer-reviewed

Research Article

William Poole,

Current address: California Institute of Technology, Pasadena, CA, United States of America

Affiliation Institute for Systems Biology, Seattle, WA, United States of America
⨯
Kalle Leinonen,

Affiliation Institute for Systems Biology, Seattle, WA, United States of America
⨯
Ilya Shmulevich,

Affiliation Institute for Systems Biology, Seattle, WA, United States of America
⨯
Theo A. Knijnenburg ,

Contributed equally to this work with: Theo A. Knijnenburg, Brady Bernard

* E-mail: Theo.Knijnenburg@systemsbiology.org (TAK); Brady.Bernard@systemsbiology.org (BB)

Affiliation Institute for Systems Biology, Seattle, WA, United States of America
⨯
Brady Bernard

Contributed equally to this work with: Theo A. Knijnenburg, Brady Bernard

* E-mail: Theo.Knijnenburg@systemsbiology.org (TAK); Brady.Bernard@systemsbiology.org (BB)

Affiliation Institute for Systems Biology, Seattle, WA, United States of America
⨯

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Gene expression
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Mutation
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Cancers and neoplasms
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Breast cancer
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Nonsense mutation
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Protein domains
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Point mutation
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Lung and intrathoracic tumors
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