A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

Christoph Thiel; Henrik Cordes; Lorenzo Fabbri; Hélène Eloise Aschmann; Vanessa Baier; Ines Smit; Francis Atkinson; Lars Mathias Blank; Lars Kuepfer

doi:10.1371/journal.pcbi.1005280

Loading metrics

Open Access

Peer-reviewed

Research Article

A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

Christoph Thiel,

Affiliation Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Worringerweg 1, Aachen, Germany
⨯
Henrik Cordes,

Affiliation Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Worringerweg 1, Aachen, Germany
⨯
Lorenzo Fabbri,

Affiliation Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Worringerweg 1, Aachen, Germany
⨯
Hélène Eloise Aschmann,

Affiliation Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Worringerweg 1, Aachen, Germany
⨯
Vanessa Baier,

Affiliation Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Worringerweg 1, Aachen, Germany
⨯
Ines Smit,

Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Francis Atkinson,

Affiliation European Molecular Biology Laboratory, European Bioinformatics Institute (EMBL-EBI), Wellcome Genome Campus, Hinxton, Cambridge, United Kingdom
⨯
Lars Mathias Blank,

Affiliation Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Worringerweg 1, Aachen, Germany
⨯
Lars Kuepfer

* E-mail: lars.kuepfer@rwth-aachen.de

Affiliation Institute of Applied Microbiology (iAMB), Aachen Biology and Biotechnology (ABBt), RWTH Aachen University, Worringerweg 1, Aachen, Germany
⨯

A Comparative Analysis of Drug-Induced Hepatotoxicity in Clinically Relevant Situations

Christoph Thiel,
Henrik Cordes,
Lorenzo Fabbri,
Hélène Eloise Aschmann,
Vanessa Baier,
Ines Smit,
Francis Atkinson,
Lars Mathias Blank,
Lars Kuepfer

Published: February 2, 2017
https://doi.org/10.1371/journal.pcbi.1005280

Reader Comments (0)

Post a new comment on this article

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cell processes
Is the Subject Area "Cell processes" applicable to this article?

Thanks for your feedback.
Dose prediction methods
Is the Subject Area "Dose prediction methods" applicable to this article?

Thanks for your feedback.
Predictive toxicology
Is the Subject Area "Predictive toxicology" applicable to this article?

Thanks for your feedback.
Biomarkers
Is the Subject Area "Biomarkers" applicable to this article?

Thanks for your feedback.
Drug administration
Is the Subject Area "Drug administration" applicable to this article?

Thanks for your feedback.
Toxicity
Is the Subject Area "Toxicity" applicable to this article?

Thanks for your feedback.
Drug metabolism
Is the Subject Area "Drug metabolism" applicable to this article?

Thanks for your feedback.
Enzyme metabolism
Is the Subject Area "Enzyme metabolism" applicable to this article?

Thanks for your feedback.