The Limitations of Model-Based Experimental Design and Parameter Estimation in Sloppy Systems

• Andrew White,

  Affiliation Department of Physics & Astronomy, Brigham Young University, Provo, Utah, United States of America

  http://orcid.org/0000-0001-7249-8950

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• Malachi Tolman,

  Affiliation Department of Physics & Astronomy, Brigham Young University, Provo, Utah, United States of America

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• Howard D. Thames,

  Affiliations Department of Biostatistics, UT MD Anderson Cancer Center, Houston, Texas, United States of America, Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, Houston, Texas, United States of America

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• Hubert Rodney Withers †,

  † Deceased.

  Affiliation Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, Houston, Texas, United States of America

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• Kathy A. Mason,

  Affiliation Department of Experimental Radiation Oncology, UT MD Anderson Cancer Center, Houston, Texas, United States of America

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• Mark K. Transtrum

  * E-mail: mktranstrum@byu.edu

  Affiliation Department of Physics & Astronomy, Brigham Young University, Provo, Utah, United States of America

  http://orcid.org/0000-0001-9529-9399

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