The Loss and Gain of Functional Amino Acid Residues Is a Common Mechanism Causing Human Inherited Disease

• Jose Lugo-Martinez,

  Affiliation Department of Computer Science and Informatics, Indiana University, Bloomington, Indiana, United States of America

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• Vikas Pejaver,

  Affiliation Department of Computer Science and Informatics, Indiana University, Bloomington, Indiana, United States of America

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• Kymberleigh A. Pagel,

  Affiliation Department of Computer Science and Informatics, Indiana University, Bloomington, Indiana, United States of America

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• Shantanu Jain,

  Affiliation Department of Computer Science and Informatics, Indiana University, Bloomington, Indiana, United States of America

  http://orcid.org/0000-0002-7169-9483

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• Matthew Mort,

  Affiliation Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom

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• David N. Cooper,

  Affiliation Institute of Medical Genetics, School of Medicine, Cardiff University, Cardiff, United Kingdom

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• Sean D. Mooney ,

  * E-mail: sdmooney@uw.edu (SDM); predrag@indiana.edu (PR)

  Affiliation Department of Biomedical Informatics and Medical Education, University of Washington, Seattle, Washington, United States of America

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• Predrag Radivojac

  * E-mail: sdmooney@uw.edu (SDM); predrag@indiana.edu (PR)

  Affiliation Department of Computer Science and Informatics, Indiana University, Bloomington, Indiana, United States of America

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