A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett’s Esophagus

Kit Curtius; Chao-Jen Wong; William D. Hazelton; Andrew M. Kaz; Amitabh Chak; Joseph E. Willis; William M. Grady; E. Georg Luebeck

doi:10.1371/journal.pcbi.1004919

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Open Access

Peer-reviewed

Research Article

A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett’s Esophagus

Kit Curtius ,

* E-mail: kcurtius@medicine.washington.edu (KC); gluebeck@fredhutch.org (EGL)

Affiliations Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington, United States of America, Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Chao-Jen Wong,

Affiliation Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
William D. Hazelton,

Affiliation Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
Andrew M. Kaz,

Affiliations Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America, Gastroenterology Section, VA Puget Sound Health Care System, Seattle, Washington, United States of America
⨯
Amitabh Chak,

Affiliation University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America

http://orcid.org/0000-0002-0021-7862

⨯
Joseph E. Willis,

Affiliation University Hospitals Case Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, United States of America
⨯
William M. Grady,

Affiliations Division of Gastroenterology, University of Washington School of Medicine, Seattle, Washington, United States of America, Clinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯
E. Georg Luebeck

* E-mail: kcurtius@medicine.washington.edu (KC); gluebeck@fredhutch.org (EGL)

Affiliation Program in Computational Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, United States of America
⨯

A Molecular Clock Infers Heterogeneous Tissue Age Among Patients with Barrett’s Esophagus

Kit Curtius,
Chao-Jen Wong,
William D. Hazelton,
Andrew M. Kaz,
Amitabh Chak,
Joseph E. Willis,
William M. Grady,
E. Georg Luebeck

Published: May 11, 2016
https://doi.org/10.1371/journal.pcbi.1004919

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24 May 2016
01:12 GMT
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infer Posted by jmbraverman on 24 May 2016 at 01:12 GMT

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DNA methylation
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Cancer risk factors
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