Systems Pharmacology and Rational Polypharmacy: Nitric Oxide−Cyclic GMP Signaling Pathway as an Illustrative Example and Derivation of the General Case

Open Access

Peer-reviewed

Research Article

Farshid S. Garmaroudi,

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Diane E. Handy,

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
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Yang-Yu Liu,

Affiliation Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯
Joseph Loscalzo

* E-mail: jloscalzo@partners.org

Affiliation Cardiovascular Division, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, United States of America
⨯

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cGMP signaling
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Oxidative stress
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Body limbs
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Hydrogen peroxide
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Oxidation
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Pulmonary arteries
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Toxicity
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Cardiovascular therapy
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