Conflicting Selection Pressures Will Constrain Viral Escape from Interfering Particles: Principles for Designing Resistance-Proof Antivirals

• Luke I. Rast,

  Affiliations Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America, Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

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• Igor M. Rouzine,

  Current address: Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, California, United States of America

  Affiliation Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America

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• Ganna Rozhnova,

  Current address: Julius Center for Health Sciences and Primary Care, University Medical Centre Utrecht, Utrecht, The Netherlands

  Affiliation Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America

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• Lisa Bishop,

  Current address: Quantum Camp Inc., Blue Mountain Centre of Meditation, San Francisco, California, United States of America

  Affiliation Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America

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• Ariel D. Weinberger ,

  * E-mail: ariel.weinberger@wyss.harvard.edu (ADW); leor.weinberger@gladstone.ucsf.edu (LSW)

  Affiliation Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, Massachusetts, United States of America

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• Leor S. Weinberger

  * E-mail: ariel.weinberger@wyss.harvard.edu (ADW); leor.weinberger@gladstone.ucsf.edu (LSW)

  Affiliations Gladstone Institutes (Virology and Immunology), San Francisco, California, United States of America, Department of Biochemistry and Biophysics, University of California, San Francisco, San Francisco, California, United States of America, QB3: California Institute for Quantitative Biosciences, University of California, San Francisco, San Francisco, California, United States of America

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