Systems-Wide Prediction of Enzyme Promiscuity Reveals a New Underground Alternative Route for Pyridoxal 5’-Phosphate Production in E. coli

• Matthew A. Oberhardt ,

  Contributed equally to this work with: Matthew A. Oberhardt, Raphy Zarecki

  * E-mail: mattoby@gmail.com (MAO); ruppin@post.tau.ac.il (ER)

  Affiliations School of Computer Sciences and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel, Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, Maryland, United States of America

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• Raphy Zarecki ,

  Contributed equally to this work with: Matthew A. Oberhardt, Raphy Zarecki

  Affiliation School of Computer Sciences and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel

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• Leah Reshef,

  Affiliation Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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• Fangfang Xia,

  Affiliation Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, United States of America

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• Miquel Duran-Frigola,

  Affiliation Joint IRB-BSC-CRG Program in Computational Biology, Institute for Research in Biomedicine (IRB Barcelona), Barcelona, Spain

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• Rachel Schreiber,

  Affiliation Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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• Christopher S. Henry,

  Affiliation Mathematics and Computer Science Division, Argonne National Laboratory, Argonne, Illinois, United States of America

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• Nir Ben-Tal,

  Affiliation Department of Biochemistry and Molecular Biology, George S. Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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• Daniel J. Dwyer ,

  ¶‡ DD, UG, and ER are equally contributing last authors.

  Affiliation Department of Cell Biology and Molecular Genetics, Institute for Physical Science and Technology, Department of Bioengineering, Maryland Pathogen Research Institute, University of Maryland, College Park, Maryland, United States of America

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• Uri Gophna ,

  ¶‡ DD, UG, and ER are equally contributing last authors.

  Affiliation Department of Molecular Microbiology and Biotechnology, Faculty of Life Sciences, Tel Aviv University, Tel Aviv, Israel

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• Eytan Ruppin

  * E-mail: mattoby@gmail.com (MAO); ruppin@post.tau.ac.il (ER)

  ¶‡ DD, UG, and ER are equally contributing last authors.

  Affiliations School of Computer Sciences and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel, Center for Bioinformatics and Computational Biology, Department of Computer Science, University of Maryland, College Park, Maryland, United States of America

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