The siRNA Non-seed Region and Its Target Sequences Are Auxiliary Determinants of Off-Target Effects

• Piotr J. Kamola,

  Affiliations Department of Surgery and Cancer, Imperial College London, London, United Kingdom, Safety Assessment, GlaxoSmithKline R&D, Ware, Hertfordshire, United Kingdom, Computational Biology, GlaxoSmithKline R&D, Stevenage, Hertfordshire, United Kingdom, Centre for Radiation, Chemical and Environmental Hazards, Public Health England, Harwell Science and Innovation Campus, United Kingdom

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• Yuko Nakano,

  Affiliation Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan

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• Tomoko Takahashi,

  Affiliation Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan

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• Paul A. Wilson,

  Affiliation Computational Biology, GlaxoSmithKline R&D, Stevenage, Hertfordshire, United Kingdom

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• Kumiko Ui-Tei

  * E-mail: ktei@bs.s.u-tokyo.ac.jp

  Affiliations Department of Biological Sciences, University of Tokyo, Bunkyo, Tokyo, Japan, Department of Computational Biology and Medical Sciences, University of Tokyo, Kashiwa, Chiba, Japan

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