A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ

Daniel Yakubovich; Shai Berlin; Uri Kahanovitch; Moran Rubinstein; Isabella Farhy-Tselnicker; Boaz Styr; Tal Keren-Raifman; Carmen W. Dessauer; Nathan Dascal

doi:10.1371/journal.pcbi.1004598

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Peer-reviewed

Research Article

A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ

Daniel Yakubovich ,

Contributed equally to this work with: Daniel Yakubovich, Shai Berlin, Uri Kahanovitch

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯
Shai Berlin ,

Contributed equally to this work with: Daniel Yakubovich, Shai Berlin, Uri Kahanovitch

Current address: Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, United States of America

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯
Uri Kahanovitch ,

Contributed equally to this work with: Daniel Yakubovich, Shai Berlin, Uri Kahanovitch

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯
Moran Rubinstein,

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯
Isabella Farhy-Tselnicker,

Current address: Molecular Neurobiology Laboratory, Salk Institute for Biological Studies, La Jolla, California, United States of America

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯
Boaz Styr,

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯
Tal Keren-Raifman,

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯
Carmen W. Dessauer,

Affiliation Department of Integrative Biology and Pharmacology, University of Texas Health Science Center, Houston, Texas, United States of America
⨯
Nathan Dascal

* E-mail: dascaln@tauex.tau.ac.il

Affiliation Department of Physiology and Pharmacology and Sagol School of Neuroscience, Tel Aviv University, Tel Aviv, Israel
⨯

A Quantitative Model of the GIRK1/2 Channel Reveals That Its Basal and Evoked Activities Are Controlled by Unequal Stoichiometry of Gα and Gβγ

Daniel Yakubovich,
Shai Berlin,
Uri Kahanovitch,
Moran Rubinstein,
Isabella Farhy-Tselnicker,
Boaz Styr,
Tal Keren-Raifman,
Carmen W. Dessauer,
Nathan Dascal

Published: November 6, 2015
https://doi.org/10.1371/journal.pcbi.1004598

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