FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

David Bednar; Koen Beerens; Eva Sebestova; Jaroslav Bendl; Sagar Khare; Radka Chaloupkova; Zbynek Prokop; Jan Brezovsky; David Baker; Jiri Damborsky

doi:10.1371/journal.pcbi.1004556

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Open Access

Peer-reviewed

Research Article

FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

David Bednar ,

Contributed equally to this work with: David Bednar, Koen Beerens

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
⨯
Koen Beerens ,

Contributed equally to this work with: David Bednar, Koen Beerens

Affiliation Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic
⨯
Eva Sebestova,

Affiliation Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic
⨯
Jaroslav Bendl,

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic, Department of Information Systems, Faculty of Information Technology, Brno University of Technology, Brno, Czech Republic
⨯
Sagar Khare,

Affiliation Department of Chemistry and Chemical Biology, Rutgers University, Piscataway, New Jersey, United States of America
⨯
Radka Chaloupkova,

Affiliation Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic
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Zbynek Prokop,

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic, Enantis, Ltd., Brno, Czech Republic
⨯
Jan Brezovsky,

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic
⨯
David Baker,

Affiliation Department of Biochemistry, University of Washington, Seattle, Washington, United States of America
⨯
Jiri Damborsky

* E-mail: jiri@chemi.muni.cz

Affiliations Loschmidt Laboratories, Department of Experimental Biology and Research Centre for Toxic Compounds in the Environment RECETOX, Masaryk University, Brno, Czech Republic, International Clinical Research Center, St. Anne's University Hospital Brno, Brno, Czech Republic, Enantis, Ltd., Brno, Czech Republic
⨯

FireProt: Energy- and Evolution-Based Computational Design of Thermostable Multiple-Point Mutants

David Bednar,
Koen Beerens,
Eva Sebestova,
Jaroslav Bendl,
Sagar Khare,
Radka Chaloupkova,
Zbynek Prokop,
Jan Brezovsky,
David Baker,
Jiri Damborsky

Published: November 3, 2015
https://doi.org/10.1371/journal.pcbi.1004556

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