Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance

Daniel Nichol; Peter Jeavons; Alexander G. Fletcher; Robert A. Bonomo; Philip K. Maini; Jerome L. Paul; Robert A. Gatenby; Alexander R.A. Anderson; Jacob G. Scott

doi:10.1371/journal.pcbi.1004493

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Open Access

Peer-reviewed

Research Article

Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance

Daniel Nichol ,

* E-mail: dnichol@cs.ox.ac.uk (DN); jacob.g.scott@gmail.com (JGS)

Affiliations Department of Computer Science, University of Oxford, Oxford, United Kingdom, Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
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Peter Jeavons,

Affiliation Department of Computer Science, University of Oxford, Oxford, United Kingdom
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Alexander G. Fletcher,

Affiliation Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom
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Robert A. Bonomo,

Affiliation Department of Medicine, Louis Stokes Department of Veterans Affairs Hospital, Cleveland Ohio, United States of America,
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Philip K. Maini,

Affiliation Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom
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Jerome L. Paul,

Affiliation School of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, Ohio, United States of America
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Robert A. Gatenby,

Affiliation Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
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Alexander R.A. Anderson,

Affiliation Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America
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Jacob G. Scott

* E-mail: dnichol@cs.ox.ac.uk (DN); jacob.g.scott@gmail.com (JGS)

Affiliations Department of Integrated Mathematical Oncology, H. Lee Moffitt Cancer Center and Research Institute, Tampa, Florida, United States of America, Wolfson Centre for Mathematical Biology, Mathematical Institute, University of Oxford, Oxford, United Kingdom
⨯

Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance

Daniel Nichol,
Peter Jeavons,
Alexander G. Fletcher,
Robert A. Bonomo,
Philip K. Maini,
Jerome L. Paul,
Robert A. Gatenby,
Alexander R.A. Anderson,
Jacob G. Scott

Published: September 11, 2015
https://doi.org/10.1371/journal.pcbi.1004493
See the preprint

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25 Sep 2015
21:37 GMT
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Are medical applications realistic? Posted by krcrona on 25 Sep 2015 at 10:57 GMT

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