Innate Immunity and the Inter-exposure Interval Determine the Dynamics of Secondary Influenza Virus Infection and Explain Observed Viral Hierarchies

• Pengxing Cao,

  Affiliation Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia

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• Ada W. C. Yan,

  Affiliation Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia

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• Jane M. Heffernan,

  Affiliations Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia, Modelling Infection and Immunity Lab, Centre for Disease Modelling, York Institute for Health Research, York University, Toronto, Ontario, Canada, Mathematics and Statistics, York University, Toronto, Ontario, Canada

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• Stephen Petrie,

  Affiliation Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia

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• Robert G. Moss,

  Affiliation Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia

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• Louise A. Carolan,

  Affiliation WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia

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• Teagan A. Guarnaccia,

  Affiliation WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia

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• Anne Kelso,

  Affiliation WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia

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• Ian G. Barr,

  Affiliation WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia

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• Jodie McVernon,

  Affiliations Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia, Modelling and Simulation, Infection and Immunity Theme, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, Victoria, Australia

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• Karen L. Laurie,

  Affiliation WHO Collaborating Centre for Reference and Research on Influenza at the Peter Doherty Institute for Infection and Immunity, Parkville, Victoria, Australia

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• James M. McCaw

  * E-mail: jamesm@unimelb.edu.au

  Affiliations Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Australia, Modelling and Simulation, Infection and Immunity Theme, Murdoch Childrens Research Institute, The Royal Children’s Hospital, Parkville, Victoria, Australia, School of Mathematics and Statistics, The University of Melbourne, Melbourne, Australia

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