Rigidity Emerges during Antibody Evolution in Three Distinct Antibody Systems: Evidence from QSFR Analysis of Fab Fragments

• Tong Li,

  Affiliation Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America

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• Malgorzata B. Tracka,

  Affiliation Department of Formulation Sciences, MedImmune Ltd., Cambridge, United Kingdom

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• Shahid Uddin,

  Affiliation Department of Formulation Sciences, MedImmune Ltd., Cambridge, United Kingdom

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• Jose Casas-Finet,

  Affiliation Analytical Biochemistry Department, MedImmune LLC, Gaithersburg, Maryland, United States of America

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• Donald J. Jacobs ,

  * E-mail: djacobs1@uncc.edu (DJJ); drlivesa@uncc.edu (DRL)

  Affiliation Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America

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• Dennis R. Livesay

  * E-mail: djacobs1@uncc.edu (DJJ); drlivesa@uncc.edu (DRL)

  Affiliation Department of Bioinformatics and Genomics, University of North Carolina at Charlotte, Charlotte, North Carolina, United States of America

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