Design of Protein Multi-specificity Using an Independent Sequence Search Reduces the Barrier to Low Energy Sequences

Open Access

Peer-reviewed

Research Article

Alexander M. Sevy,

Affiliation Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America
⨯
Tim M. Jacobs,

Affiliation Department of Biochemistry, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
⨯
James E. Crowe Jr.,

Affiliation Vanderbilt Vaccine Center, Vanderbilt University Medical Center, Nashville, Tennessee, United States of America
⨯
Jens Meiler

* E-mail: jens.meiler@vanderbilt.edu

Affiliations Center for Structural Biology, Vanderbilt University, Nashville, Tennessee, United States of America, Department of Chemistry, Vanderbilt University, Nashville, Tennessee, United States of America
⨯

Reader Comments (0)

Algorithms
Is the Subject Area "Algorithms" applicable to this article?

Thanks for your feedback.
DNA-binding proteins
Is the Subject Area "DNA-binding proteins" applicable to this article?

Thanks for your feedback.
Molecular evolution
Is the Subject Area "Molecular evolution" applicable to this article?

Thanks for your feedback.
Natural selection
Is the Subject Area "Natural selection" applicable to this article?

Thanks for your feedback.
Optimization
Is the Subject Area "Optimization" applicable to this article?

Thanks for your feedback.
Convergent evolution
Is the Subject Area "Convergent evolution" applicable to this article?

Thanks for your feedback.
Sequence similarity searching
Is the Subject Area "Sequence similarity searching" applicable to this article?

Thanks for your feedback.
Macromolecular design
Is the Subject Area "Macromolecular design" applicable to this article?

Thanks for your feedback.