Causal Modeling of Cancer-Stromal Communication Identifies PAPPA as a Novel Stroma-Secreted Factor Activating NFκB Signaling in Hepatocellular Carcinoma

• Julia C. Engelmann ,

  * E-mail: julia.engelmann@ukr.de (JCE); rainer.spang@ukr.de (RS); claus.hellerbrand@ukr.de (CH)

  Affiliation Department of Statistical Bioinformatics, University of Regensburg, Regensburg, Germany

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• Thomas Amann,

  Affiliation Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

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• Birgitta Ott-Rötzer,

  Affiliation Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

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• Margit Nützel,

  Affiliation Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

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• Yvonne Reinders,

  Affiliation Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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• Jörg Reinders,

  Affiliation Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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• Wolfgang E. Thasler,

  Affiliation Biobank under the authority of Human Tissue and Cell Research (HTCR) and Center for Liver Cell Research, Department of General, Visceral, Transplantation, Vascular and Thoracic Surgery, Hospital of Ludwig-Maximilians-University of Munich, Munich, Germany

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• Theresa Kristl,

  Affiliation Department of Molecular Biology, Division of Chemistry and Bioanalytics, University of Salzburg, Salzburg, Austria

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• Andreas Teufel,

  Affiliation Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

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• Christian G. Huber,

  Affiliation Department of Molecular Biology, Division of Chemistry and Bioanalytics, University of Salzburg, Salzburg, Austria

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• Peter J. Oefner,

  Affiliation Institute of Functional Genomics, University of Regensburg, Regensburg, Germany

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• Rainer Spang ,

  Contributed equally to this work with: Rainer Spang, Claus Hellerbrand

  * E-mail: julia.engelmann@ukr.de (JCE); rainer.spang@ukr.de (RS); claus.hellerbrand@ukr.de (CH)

  Affiliation Department of Statistical Bioinformatics, University of Regensburg, Regensburg, Germany

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• Claus Hellerbrand

  Contributed equally to this work with: Rainer Spang, Claus Hellerbrand

  * E-mail: julia.engelmann@ukr.de (JCE); rainer.spang@ukr.de (RS); claus.hellerbrand@ukr.de (CH)

  Affiliation Department of Internal Medicine I, University Hospital Regensburg, Regensburg, Germany

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