Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling

David W. P. Dolan; Anze Zupanic; Glyn Nelson; Philip Hall; Satomi Miwa; Thomas B. L. Kirkwood; Daryl P. Shanley

doi:10.1371/journal.pcbi.1004246

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Peer-reviewed

Research Article

Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling

David W. P. Dolan ,

Contributed equally to this work with: David W. P. Dolan, Anze Zupanic

Affiliations School of Biological and Biomedical Biosciences, Durham University, Durham, United Kingdom, Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Anze Zupanic ,

Contributed equally to this work with: David W. P. Dolan, Anze Zupanic

Affiliations Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom, Eawag—Swiss Federal Institute of Aquatic Science and Technology, Dübendorf, Switzerland
⨯
Glyn Nelson,

Affiliation Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯
Philip Hall,

Affiliation Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom
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Satomi Miwa,

Affiliation Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom
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Thomas B. L. Kirkwood,

Affiliation Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom
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Daryl P. Shanley

* E-mail: daryl.shanley@ncl.ac.uk

Affiliation Centre for Integrative Systems Biology of Ageing and Nutrition, Newcastle University Institute for Ageing, Newcastle University, Newcastle upon Tyne, United Kingdom
⨯

Integrated Stochastic Model of DNA Damage Repair by Non-homologous End Joining and p53/p21- Mediated Early Senescence Signalling

David W. P. Dolan,
Anze Zupanic,
Glyn Nelson,
Philip Hall,
Satomi Miwa,
Thomas B. L. Kirkwood,
Daryl P. Shanley

Published: May 28, 2015
https://doi.org/10.1371/journal.pcbi.1004246

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DNA damage
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DNA repair
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Biochemical simulations
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Non-homologous end joining
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Redox signaling
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Dose prediction methods
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Phosphorylation
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Cancers and neoplasms
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