Keys to Lipid Selection in Fatty Acid Amide Hydrolase Catalysis: Structural Flexibility, Gating Residues and Multiple Binding Pockets

• Giulia Palermo,

  Affiliation Laboratory of Molecular Modeling and Drug Discovery, Istituto Italiano di Tecnologia, Genova, Italy

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• Inga Bauer,

  Affiliation CompuNet, Istituto Italiano di Tecnologia, Genova, Italy

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• Pablo Campomanes,

  Affiliation Laboratory of Computational Chemistry and Biochemistry, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Andrea Cavalli,

  Affiliations CompuNet, Istituto Italiano di Tecnologia, Genova, Italy, Department of Pharmacy and Biotechnology, University of Bologna, Bologna, Italy

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• Andrea Armirotti,

  Affiliation D3-PharmaChemistry, Istituto Italiano di Tecnologia, Genova, Italy

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• Stefania Girotto,

  Affiliation CompuNet, Istituto Italiano di Tecnologia, Genova, Italy

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• Ursula Rothlisberger,

  Affiliation Laboratory of Computational Chemistry and Biochemistry, Institute of Chemical Sciences and Engineering, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland

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• Marco De Vivo

  * E-mail: marco.devivo@iit.it

  Affiliation Laboratory of Molecular Modeling and Drug Discovery, Istituto Italiano di Tecnologia, Genova, Italy

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