Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks

Daniel K. Wells; Yishan Chuang; Louis M. Knapp; Dirk Brockmann; William L. Kath; Joshua N. Leonard

doi:10.1371/journal.pcbi.1004181

Loading metrics

Open Access

Peer-reviewed

Research Article

Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks

Daniel K. Wells,

Affiliations Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois, United States of America, Northwestern University Physical Sciences-Oncology Center, Evanston, Illinois, United States of America
⨯
Yishan Chuang,

Affiliation Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America
⨯
Louis M. Knapp,

Affiliation Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America
⨯
Dirk Brockmann,

Current address: Robert Koch Institute, Berlin, Germany

Affiliations Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois, United States of America, Northwestern University Physical Sciences-Oncology Center, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America, Northwestern Institute on Complex Science, Northwestern University, Evanston, Illinois, United States of America, Institute for Theoretical Biology, Humboldt University Berlin, Berlin, Germany
⨯
William L. Kath,

Affiliations Department of Engineering Sciences and Applied Mathematics, Northwestern University, Evanston, Illinois, United States of America, Northwestern University Physical Sciences-Oncology Center, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America, Northwestern Institute on Complex Science, Northwestern University, Evanston, Illinois, United States of America, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America
⨯
Joshua N. Leonard

* E-mail: j-leonard@northwestern.edu

Affiliations Northwestern University Physical Sciences-Oncology Center, Evanston, Illinois, United States of America, Department of Chemical and Biological Engineering, Northwestern University, Evanston, Illinois, United States of America, Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Evanston, Illinois, United States of America, Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois, United States of America
⨯

Spatial and Functional Heterogeneities Shape Collective Behavior of Tumor-Immune Networks

Daniel K. Wells,
Yishan Chuang,
Louis M. Knapp,
Dirk Brockmann,
William L. Kath,
Joshua N. Leonard

Published: April 23, 2015
https://doi.org/10.1371/journal.pcbi.1004181

Reader Comments (1)

Post a new comment on this article

0 Responses

29 Apr 2015
18:46 GMT
Most Recent

A New take on What's Carcinogenic Posted by JohnDMarano on 29 Apr 2015 at 18:46 GMT

Subject Areas
?

For more information about PLOS Subject Areas, click here.
We want your feedback. Do these Subject Areas make sense for this article? Click the target next to the incorrect Subject Area and let us know. Thanks for your help!

Cancers and neoplasms
Is the Subject Area "Cancers and neoplasms" applicable to this article?

Thanks for your feedback.
Malignant tumors
Is the Subject Area "Malignant tumors" applicable to this article?

Thanks for your feedback.
Macrophages
Is the Subject Area "Macrophages" applicable to this article?

Thanks for your feedback.
Cancer treatment
Is the Subject Area "Cancer treatment" applicable to this article?

Thanks for your feedback.
Simulation and modeling
Is the Subject Area "Simulation and modeling" applicable to this article?

Thanks for your feedback.
Immune suppression
Is the Subject Area "Immune suppression" applicable to this article?

Thanks for your feedback.
Metastatic tumors
Is the Subject Area "Metastatic tumors" applicable to this article?

Thanks for your feedback.
Oxygen
Is the Subject Area "Oxygen" applicable to this article?

Thanks for your feedback.